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Introduction: Benign prostate hyperplasia is a proliferation of stromal cells and epithelial cells which results an enlargement of the prostate gland and can cause obstruction of the urinary tract. Adenocarcinoma prostate is an invasive carcinoma consisting of a neoplasm of prostate epithelial cells with secretory cell differentiation. Abnormal growth of the prostate gland like benign lesions and malignant lesions are generally affected by androgen receptor (AR). The aim of this research is to analyse the comparison of AR expression in benign prostate hyperplasia and adenocarcinoma prostate.

Methods: The design of this research is analiytical study with cross sectional approach. The samples are 18 cases of benign prostate hyperplasia and 20 cases of adenocarcinoma prostate. The samples are observed only once and at a time.

Results: The average age of the adenocarcinoma prostate case was 63.95 ± 12.03 years (age range 33-84 years) while in the benign prostate hyperplasia case, the average age was 66.78 ± 9.49 (age range 54–89 years). There are no different about the expression of AR in benign prostate hyperplasia and adenocarcinoma prostate used Allred scores. There was a weak and negative correlation between Gleason score and AR expression in the adenocarcinoma prostate case group (p=0.237).

Conclusion: There are no differences related to the expression of AR between the case of adenocarcinoma prostate and benign prostatic hyperplasia.


Adenocarcinoma prostate Androgen receptor Benign prostate hyperplasia

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How to Cite
Engki Aditya, Pramudhito, D., Aspitriani, & Legiran. (2022). Comparison of Androgen Receptor Expression in Patients with Benign Prostate Hyperplasia and Adenocarcinoma Prostate. Sriwijaya Journal of Surgery, 5(2), 502-508.