Article Sidebar
Main Article Content
Abstract
Introduction. Hirschsprung-associated enterocolitis (HAEC) is the most common life-threatening complication of Hirschsprung's disease. The incidence of HAEC ranges from 6-60% before and 25-37% after surgery. Rectal irrigation with warm 0.9% NaCl has been shown to reduce the incidence of HAEC before and after surgery. Rectal irrigation plays a role in preventing faecal stasis by evacuating feces, as well as reducing bacterial colonies in HAEC patients. This study aims to determine the effectiveness of rectal irrigation with warm 0.9% NaCl on the number of intestinal microbiota colonies in Hirschsprung-associated enterocolitis patients at Dr. Mohammad Hoesin Hospital Palembang.
Method: A randomized clinical trial without comparison in the form of an add on trial, open label which is an experiment by providing additional measures to a group with the same standard and different treatment. Patients were divided into three groups, including antibiotics ampicillin, ceftriaxone, metronidazole and 0.9% NaCl irrigation 1 time per 24 hours (Group 1), per 12 hours (Group 2), and per 8 hours (Group 3). Comparisons were tested using paired T-test or Wilcoxon's, p-value <0.05 was considered statistically significant.
Results: HAEC patients who received irrigation treatment 1 time, the number of bacterial colonies did not change, in patients with irrigation treatment 2 times the number of colonies decreased by 171,428.57 ± 138,013.11 colonies/ml, while in patients with irrigation treatment 3 times the number of colonies was reduced. colonies decreased by 214.285.71 ± 177.281.05 colonies/ml. There was a significant difference in the number of bacterial colonies before and after irrigation treatment with a frequency of 2 times (p = 0.026) and 3 times (p = 0.027) while with a frequency of 1 time there was no difference in the number of bacterial colonies before and after treatment (p = 1,000).
Conclusion: Rectal irrigation with warm NaCl 0.9% as much as 20 ml/kg with a frequency of 2 times was effective in reducing the number of gut microbiome colonies. There was no significant difference in the number of bacterial colonies between the 2 and 3 times irrigation frequency groups.
Keywords
Article Details
1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.